SYNTHESIS AND SCREENING OF SOME NOVEL CHALCONE DERIVATIVES CONTAINING FURAN RING AS POTENTIAL ANTIMICROBIAL AGENTS

Shaik Khadar Yazdan* and G. Vidya Sagar

ABSTRACT

Chalcones are a category of natural products which posses a wide variety of biological activities. Keeping in mind the diverse array of biological activities associated with chalcones a series of some new chalcones containing different substituents were synthesized by Claisen-Schmidt condensation of 2-acetyl-5-bromofuran with various substituted aromatic and heteroaromatic aldehydes. The synthesized chalcones were purified by recrystallization and column chromatography. The characterization of the purified chalcones was made by IR, 1H NMR and elemental analysis data. These compounds were further screened for their antimicrobial activity. When these chalcones were evaluated for antibacterial and antifungal activities, some of them found to possess significant biological activity when compared to standard drugs.

Keywords: Chalcone, Claisen-Schmidt condensation, Antimicrobial activity.