SMALL INTESTINAL BACTERIAL OVERGROWTH: TOO MUCH OF A GOOD THING CAN BE A BAD THING

*Prof. Dr. Badmanaban Ramalingam, Helan Kurian and Prof. Dr. Dhrubo Jyoti Sen

ABSTRACT

Small intestinal bacterial overgrowth (SIBO), defined as excessive bacteria in the small intestine, remains a poorly understood disease. Initially thought to occur in only a small number of patients, it is now apparent that this disorder is more prevalent than previously thought. Patients with SIBO vary in presentation, from being only mildly symptomatic to suffering from chronic diarrhea, weight loss, and malabsorption. A number of diagnostic tests are currently available, although the optimal treatment regimen remains elusive. Recently there has been renewed interest in SIBO and its putative association with irritable bowel syndrome. In this comprehensive review, the discussion will be on the epidemiology, pathogenesis, clinical manifestations, diagnosis and treatment of SIBO.

Keywords: Small intestinal bacterial overgrowth (SIBO), defined as excessive bacteria in the small intestine, remains a poorly understood disease. Initially thought to occur in only a small number of patients, it is now apparent that this disorder is more prevalent