THERAPEUTIC ADVANTAGES OF BLOCKING ANGIOTENSIN II (AT1) RECEPTOR: LVH MASS REGRESSION, ACTIVATION OF PPAR GAMMA RECEPTOR INFLUENCED GENE AND ANTI-AGEING EFFECTS

Dr. Mohammed Zubair and Dr. M. Ishaq*

ABSTRACT

The objective of this review is to critically analyse the therapeutic advantages of Angiotensin II receptor (AT1) blockers. While different classes of anti-hypertensive drugs are effective in keeping the systolic and diastolic blood pressure within normal range, the blocking of Angiotensin II AT 1 receptors by ARBs provides additional therapeutic advantages. These beneficial effects are regression of left ventricular hypertrophy (LVH), activation of genes influenced by Peroxisome proliferator activator receptor gamma (PPAR gamma). and anti-ageing effects. Moreover it has been also observed that those essential hypertension (E-HTN) patients who were on ARBs recorded lowest incidence of T2DM compared to those who were on other classes of anti-hypertensive medications. The aforementioned therapeutic advantages of ARBs in specific clinical conditions have been discussed briefly, highlighting their potential therapeutic advantages.

Keywords: Angiotensin II receptor, Anti-hypertensives, LVH mass, PPAR gamma receptors, Anti-ageing effects.