EVALUATION OF INTERFERON-? PRODUCTION POTENTIAL OF IMMUNE CELLS AND THE LEVEL OF CRYOGLOBULINS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B AND C IN UZBEK POPULATION

Rozumbetov R. J., Ismailova A. A., Petrova T. A., Dolimov T. K.*, Kasimova M. S., Rakhimjanov A. A., Saydaliev A. E., Nigmatova L. M. and Adilov D. G.

ABSTRACT

Interferon-α (IFN-α) is the key cytokine in defense against viruses. Major IFN-α producer is plasmacytoid dendritic cells, which reside mainly in blood. Spontaneous and mitogen-induced productions are very informative characteristics of immune cells potential, which play crucial role in clearance of viruses. Nowadays, viral hepatitis imposes heavy burden on many countries healthcare, and countries of Central Asia aren’t exception. In order to study regional particularities of viral hepatitis in Uzbekistan, our laboratory has studied spontaneous and mitogen-induced production of IFN-α in patients with chronic viral hepatitis B and C (CVHC and CVHB) of Uzbek population. Conclusion: In patients with CVHC and CVHB spontaneous production of IFN-α didn’t differ significantly in comparison with results of control group.Whereas mitogen-induced production of IFN-α was nearly twice less than in control group.

Keywords: Spontaneous, mitogen-induced, production of intereron-?, cryoglobulins, hepatitis B and C.