SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND COMPUTATIONAL STUDIES OF SOME SULFONAMIDE DERIVATIVES POSSESSING THIADIAZOLE AND INDOLE NUCLEUS

Mohammad Arshad*

ABSTRACT

The synthesis of N-{5-[1-(substituted-phenylsulfonyl)-1H-indol-3-yl]-1, 3, 4-thiadiazol-2-yl}-substituted-benzenesulfonamide (1-5), was performed followed by the computational screening. The synthesized analogues were the evaluated for the antimicrobial assessment against Gram (+ve & -ve) pathogens such as S. aureus, S. epidermidis, P. mirabilis and E. coli. The findings portrayed that all the component were in compliance with the Lipinski Rule of Five and the bioactivity score is in active zone. The synthesized analogues showed better activity than the “Ciprofloxacin”.

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