SALIVARY BIOMARKERS FOR EARLY DIAGNOSIS OF ORAL CANCER

Dr. Neha Agrawal, Dr. N. D. Gupta, Dr. Afshan Bey, Dr. R. K. Tewari, Dr. Pramod Yadav, Dr. Amit Kumar Garg

ABSTRACT

Oral cancer is one of the major global public health problems and is the sixth most common human malignancy. Oral squamous cell carcinoma (OSCC) accounts for more than 90% of all oral cancer. The high morbidity rate in OSCC can be attributed to the delay in the diagnosis of the disease. Saliva, a watery and frothy substance produced in the mouth of human is in direct contact with the oral cancer lesion. Hence, the abnormal DNA, RNA, protein molecules discharged by the cancer cells can be easily acquired from saliva. Detection of oral cancer by The use of salivary biomarker can serve as a noninvasive, cost effective and valid method which could easily employed for early detection, monitoring post therapy status, prognosis of oral cancer patients. This article aims to discuss various salivary biomarkers and their implications in oral cancer.

Keywords: Oral Cancer, Biomarkers, Saliva, DNA, Mrna.