SERUM LEPTIN, ADIPONECTIN CONCENTRATION AND CENTRAL ADIPOSITY PARAMETERS IN EGYPTIAN PATIENT WITH BARRETT'S ESOPHAGUS AND GASTROESOPHAGEALREFLUXDISEASE

Ahmed A. Massoud, Sayed Farouk M, El Sayed I. Mugahed*, Sayed M. Taelb and Ahmed M. El Gaml 

ABSTRACT

Persons diagnosed with Barrett’s esophagus (BE) are at increased risk of developing esophageal adenocarcinoma (EA). Obesity is a major risk factor for both BE and EA. The purpose of this study was to determine the extent to which the adipokines leptin and adiponectin, both of which are deregulated in obese states, mediate the obesity-BE relationship as regard waist circumference is parameter of central adiposity. In this cross sectional study based in Egypt, 49 male and 41 female compared with 18 male and 12 female as controls from the general population. Relationships between leptin and adiponectin, obesity, and BE were examined and showed that serum leptin have shown positive associations with BE that may be involved in the pathology and metaplasia after long standing GERD among Egyptian people. The study showed that there is positive relationship between serum leptin level and degree of the disease and the highest level seen in group (B) which is Barret;s group proving that leptin has positive relationship with WC and Barret's. occurance Receiver operating characteristics (ROC) curve was define the best cut off value of serum leptin between GERD and Barret's groups which was > 40 ng/ml, area under the curve = 1, with sensitivity of 100%, specificity of .% 93.3%, positive predictive value of 93.7% and negative predictive value of 100%. In the current study we found negative relationship between fasting serum adiponectin and degree of disease in the 4 groups. In the current study we found negative relationship between fasting serum adiponectin and degree of disease in the 4 groups denoting that the advanced disease the lower serum adiponectin., respectively. Our study results are consistent with the notion that circulating leptin partially mediate the obesity-BE relationship in, Egyptian. Leptin and adiponectin’s role in the progression from GERD to BE and on to EA should be further studied.

Keywords: Barret's Esohagus (BE), Leptin, Adiponectin, Gastro- esophageal reflux (diseaseGERD, waist circumference) WC.