ANTI-INFLAMMATORY AND PHYTOCONSTITUENTS OF TEUCRIUM OLIVERIANUM GING. EX. BENTH

Ibrahim M. El-Ashmawy*

ABSTRACT

Many species of Teucrium were used traditionally in treatment of inflammatory disorders. The present study aimed to assess the anti-inflammatory effect of methanolic extract of aerial parts of Teucrium oliverianum Ging. ex. Benth. (family, Lamiaceae). The extract was evaluated using the carrageenan-induced rat paw edema (Acute and sub-acute models), and turpentine oil–induced granuloma pouch bioassay. The phytoconstituents were also investigated. The plant extract of Teucrium oliverianum exhibited marked anti-inflammatory activity in the both phases of carrageenan induced acute edema test. Moreover, the activity in carrageenan induced sub-acute edema test for the extract of Teucrium oliverianum in a dose-dependent manner. The plant extract of Teucrium oliverianum exhibited potential inhibitory action on exudates formation. This study proved that this plant extract could be used for the treatment of rheumatism and other inflammatory disorders.

Keywords: Anti-inflammatory, Lamiaceae, Teucrium oliverianum, Carrageenan, Turpentine oil.