ANTIHYPERGLYCAEMIC ACTIVITY OF SCLEROCARYA BIRREA IN RATS

Z. P. Deh, D. P. Koffi* and G. F. Monteomo

ABSTRACT

The trunk bark of Sclerocarya birrea (Anacardiaceae) traditionally used for the treatment of diabetes Côte d'Ivoire, have been purchased from herbalists in Abidjan. The decoction of Aqueous extract of Sclerocarya birrea (AESB) was administrated orally in the hyperglycemic rats fasting single and repeated taken at the respective doses of 35 mg/kg and 7350mg/kg. Hyperglycemia was induced by oral glucose load with the dose 4g/kg. The result after 2 hours of these EASB doses showed to hyperglycaemic rats greater antihyperglycaemic share of 30% (p<0,05; n= 8) in single and 20% in repeat doses. Sclerocarya birrea extract at 35mg/kg remained active for 4 times as single administration and after 2 days repeated administration with reductions in blood sugar levels, respectively 40% and 38% in hyperglycaemic rats made In conclusion, the administration of low dose (35 mg/kg) of AESB leading to the hypoglycaemic activity in animals given a glucose load orally. These results confirm the therapeutic indication of Sclerocarya birrea concerning its antidiabetic activity in the treatment of diabetes disease in traditional medicine.

Keywords: Sclerocarya birrea, Diabetes, Antihyperglycaemic activity.