FORMULATION AND EVALUATION OF GASTRO-RETENTIVE MUCOADHESIVE TABLETS OF ZIDOVUDINE

Kalasare Shweta N.* and Deshpande Sanjeev V.

ABSTRACT

Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive oral drug delivery system prolongs the residence time, absorption and facilitates an intimate contact of the dosage form with the absorption surface. The aim of the present study was to develop mucoadhesive tablets of Zidovudine which were designed to prolong the gastric residence time after oral administration. Zidovudine is a pyrimidine nucleoside analogue active against HIV. Mucoadhesive tablets of Zidovudine were prepared by using different polymeric ratios of Polycarbophil, Carbopol 971G, Carbopol 934P and HPMC K4M. The tablets were evaluated for thickness, hardness, weight variation, swelling index, mucoadhesive strength, drug content uniformity, and in vitro drug release. Formulation of A9 which was formulated by using polymers Polycarbophil and HPMC K4M provided controlled release of Zidovudine over the period of 12 hrs. The cumulative % of drug release of formulation A9 was 97.01.

Keywords: Mucoadhesion, Zidovudine, Oral controlled release, Evaluation parameters, functional polymers, drug delivery.