MONITORING OF RIFAMPICIN RESISTANT TUBERCULOSIS IN NEW AND TREATED PATIENTS IN HODEIDAH, YEMEN BY USING RT – PCR

Mohammed Amood Al-Kamarany*, Mohammed Al-Azazi, Abdoalhady Al-Wakdy, Mohammed Saeef and Fadh Al Ganad

ABSTRACT

Background: Rifampicin Resistant Tuberculosis (RR - TB) is detected by using phenotypic or genotypic methods, with or without resistance to other anti-TB drugs. RR is a risk factor poor outcome in tuberculosis. Objectives: Therefore, the study aims to analyze the RR – TB in patients of Hodeidah, Yemen based on real time - polymerase chain reaction (RT - PCR) in Hodeidah, Yemen. Methods: Based on a cross sectional study, 201 subjects were collected from adults aged from 18 – 80 years of age, classified into two groups, the first group were new cases that are suffering from cough, fever, chest pain and the second group that were treated with first line of anti-TB. The RR – TB of both groups were detected by RT- PCR. Results: The results showed that 10 cases (4.97%) were RR. 9 cases were under treatment group and 1 case (0.97%) was new. Conclusion: The finding data showed that analysis of RR is very important for the determination the guideline in treatment of Tb.

Keywords: Tuberculosis, Rifampicin, Resistance, Yemen.