EFFECT OF EXCIPIENTS ON THE RELEASE OF TRIMETAZIDINE DIHYDROCHLORIDE FROM BIODEGRADABLE POLYMERIC IMPLANTS

Khadiza Mousumi Talukdar, Rifat Ara Islam, Amer Khorshed Alam, Rajia Sultana and Swarnali Islam*

ABSTRACT

The purpose of this research was to evaluate the prospect of fabrication of biodegradable implants with Trimetazidine dihydrochloride which plays an important role in prophylactic treatment of angina pectoris, ischemia, tinnitus and Meniere’s disease to achieve prolonged release of the drug in order to reduce the dosing frequency as compared to the conventional dosage form. Drug loaded implants with Chitosan and Sodium Alginate were prepared in two varying ratios of 60:40 and 70:30. As the 70:30 Chitosan-Sodium Alginate implants with 25 mg drug load produced the maximum sustained action, this formulation was explored for further development using different excipients. The implants were evaluated for loading efficiency and in-vitro drug release profiles. The results of in-vitro dissolution study were fitted into Zero order, First order, Higuchi and Korsmeyer-Peppas kinetics to elucidate the drug release mechanism. Implants were found to follow Korsmeyer-Peppas model. Also good correlations were obtained with Higuchi model. According to these models, the drug release from the implants was diffusion controlled, where the drug leaving the matrix through pores and channels formed by the entry of dissolution medium.

Keywords: Biodegradable Polymeric Implant, Chitosan, Sodium Alginate, Trimetazidine dihydrochloride.