5, 5'-TETRA HYDRO-1H, 3H-FURO [3, 4-c] FURAN-1,4-DIYLBIS (2-CHLORO-1, 3-BENZODIOXOLE, SESAMINE DERIVATIVE, NEUTRITIVE IN LOWERING HYPERGLYCEMIA

U. V. Sharmila*, Ashish Kumar Sharma and Gaurav Sharma

ABSTRACT

Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. This study was to evaluate the effectiveness of synthetic sesamine derivative (3-o-methyl-d-glucose) in normal and alloxan induced rats. The study included 30 Wistar strain albino rats and randomly divided into 5 equal groups, normal rats (Only fed with normal rat feed), alloxan monohydrate 150mg/kg BW rats, sesamin derivative 10mg/kg BW, alloxan monohydrate 150mg/kg BW rats+ sesamin derivative 10mg/kg BW, Alloxan monohydrate, reference control i.e., Standard drug Glibenclamide 10 mg/kg BW was administered for 28 days for various biochemical analysis. The induction of diabetes has caused significant initial increase in the fasting blood glucose levels of all the groups. The diabetic control group shows significant increase throughout the study period when compared with the normal control group (p<0.001). However, the extract treated groups and the standard treated group shows significant decrease in the fasting blood glucose levels when compared with diabetic control (p<0.001) which was determined on the 7th and 14th day of experiment. SGOT, SGPT and ALP, show significantly lower levels of SGOT, SGPT and ALP in comparison to the diabetic control group (p<0.001). Fat accumulation in liver and inflammation were reduced with sesamine derivative. Sesamine derivative can provide a safe and effective option that may be useful in clinical practice to lower hyperglymia.

Keywords: Diabetes, Alloxan monohydrate, Glibenclamide, ALP.