DOCKING STUDIES OF BCL-2 WITH HEMIDESMUS INDICUS COMPOUNDS FOR ANTI-CANCER STUDIES

B. Kutumbarao* and Veeravilli Suryanarayana

ABSTRACT

Medicinal plants have wide spread properties due to the presence of phytocompounds and are the alternative medicines available for thosewho cannot be helped by conventional medicine. In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts. Gas chromatography and Mass Spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area. The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Out of twenty selected compounds, docking results showed Methyl-1-Cyclo Hexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.

Keywords: Anticancer, BCL-2, Docking studies, Hemidesmus indicus, Insilico studies.