SYNTHESIS OF RU-NHC COMPLEX FROM CAFFINE AND ITS ACTIVITY AGAINST MALARIAL PARASITES

Karumutchu Sitalu*, B. Hari Babu and A. Lakshmana Rao

ABSTRACT

Present day organometallic science is difficult to envision without flexible N-heterocyclic carbene ligands. Because of their remarkable soundness and auxiliary differing qualities these themes are utilized in incalculable coordination buildings in current days. Specifically, transition metal complexes bearing interchangeable and promptly accessible NHCs have been built up as intense homogeneous catalysts. This field concentrates on particular applications and adjustments. Therefore, the present scientific experts can depend on complex engineered apparatus for the functionalization of carbenes, empowering access to polydentate ligand frameworks with or without hemilabile conduct. With regards to this work, different functionalized carbene ligands were utilized to accomplish or examine particular properties of ruthenium complexes. Tetracarbene ligands are generally unbending structures which empower relatively stable mixes because of their chelating coordination mode. Be that as it may, the basic differences of these themes is frequently restricted because of the low adaptability of the ligand forerunners. Using a non-cyclic, open-chain tetraimidazolium salt, we blended Ru (II) edifices whose geometry can be adjusted relying upon the response conditions. Also, these buildings demonstrated articulated movement in the TH of ketones. The present study focuses on the synthesis of Ru-NHC and its impact on malarial parasites.

Keywords: Carbene compounds, methylated caffeine, XRD, malarial parasite.