CORRELATION OF SERUM CHOLECALCIFEROL WITH LEFT VENTRICULAR HYPERTROPHY IN ESSENTIAL HYPERTENSION

Dr. Shahbaz Ali Shah*, Dr. Israr Ahmed Chang, Dr. Kamlesh Kumar, Dr. Ramchandani Santosh and Dr. Umair Arshad Malik

ABSTRACT

Objective: Analysis of serum cholecalciferol in essential hypertension and its correlation with left ventricular hypertrophy (LVH). Study Design: Cross sectional study. Study setting & Duration: Department of Medicine, Jinnah Postgraduate and Medical center , Karachi from September 2015 to March 2016. Subjects and Methods: 100 controls and 100 diagnosed cases of essential hypertension with left ventricular hypertrophy were selected. LVH was estimated by echocardiography. Blood samples were centrifuged at 4000 rpm (10 minutes) to separate sera for biochemical estimation of serum cholecalciferol, serum calcium, serum phosphate and alkaline phosphatase. Statistical analysis was performed on statistical software (SPSS 22.0) and Microsoft excel. Results: Serum cholecalciferol was low in cases 22.84±5.10 ng/dl compared to controls 47.09±7.65 ng/dl (p=0.0001). Mean ± SD interventricular septum and posterior wall thickness was noted as 12.39±1.82 mm in cases. Serum cholecalciferol revealed negative correlation with LVH (r= - 0.774, p=0.0001). Conclusion: Low serum cholecalciferol was found in the essential hypertension with left ventricular hypertrophy.

Keywords: Left ventricular hypertrophy, Essential Hypertension, Cholecalciferol.