FORMULATION AND EVALUATION OF POLYHERBAL TRANSDERMAL GEL FOR ANTI-FUNGAL ACTIVITY

Y. Bhagyasri*, Ch. Prathyusha and N. Siva Subramanian

ABSTRACT

Conventional drug delivery system has many problems so bulk of research has now shifted from synthetic drugs to herbal drugs. This is possible because of the vast variety of bioactive molecules in the plants and their higher safety margin. Now a days there is a greater global interest in non synthetic, natural drugs derived from plant/herbal sources due to better tolerance and minimum adverse drug reactions. Herbal drugs, used in Indian systems of medicine are however claimed to be effective and safe. Phytotherapy is an alternative for fungal infection control; different species of plants are used in folk medicine. Around the world, different species play an important role on fungal infection process, for example Cassia alata is used in the treatment of fungal infection, in other studies showed the anti-fungal potential of Cedar in external route. The genus lemon grass oil, coleus aromaticus oil, Aloe vera gel constitutes an important source of Citral, Geraniol and Terpenoids these compounds are used for the fungal infection. Based on the present study, it can be concluded that polyherbal extracts possesses anti-fungal activitiy. But by doing comparision studies maximum zone of inhibition was observed for formulation (Transdermal gel) compared to polyherbal extracts.

Keywords: Lemon Grass Oil, Coleus Aromaticus Oil, Aloe Vera Transdermal Patch.