IN-DEPTH RECENT ADVANCES IN BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM.

Riad K. El Qidra*

ABSTRACT

Since the early 1947s the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. This technology has emerged as an advanced alternative to the other conventional types of drug delivery systems. The unique physiological features make the buccal mucosa as an ideal route for mucoadhesive drug delivery system. Buccal mucosa is the most suited for local, as well as systemic delivery of drugs. The various advantages associated with these systems made buccal drug delivery as a novel route of drug administration. These advantages include a rich blood supply and it is relatively permeable. In buccal drug delivery systems, mucoadhesion is the key element so various mucoadhesive polymers have been utilized in different dosages form. Thebuccal drug delivery system prolong the residence time of dosage form at the site and thus contribute to improved and/or better therapeutic performance of the drug. It is well known that the absorption of therapeutic compounds from the oral mucosa provides a direct entry of the drug into the systemic circulation, thereby avoiding first-pass hepatic metabolism and gastrointestinal drug degradation with improved bioavailability. In addition, buccal drug system is the most acceptable and palatable dosage form due to its small size, small dose and thickness of the film. Moreover, it does not require swallowing of the drug, which is most suitable for pediatric as well as geriatric patients.In this paper main focus is done on various issues like oral mucosa pathway, barriers to penetration of drug, benefits of buccal drug delivery, manufacturing methods, the theories of mucoadhesion, factors affectingmucoadhesion, different polymes utilized through buccal drug delivery, different dosage forms, evaluation parameters.

Keywords: Buccal Mucosa, Mucoadhesion, Mucoadhesive drug delivery system, Bioadhesive polymers, permeation enhancers, evaluation.