NEW SPECTROPHOTOMETRIC ESTIMATION OF NIMESULIDE IN THE TABLETS USING MIXED SOLVENCY APPROACH

Sanjay Jain*, R. K. Maheshwari, Rajesh Kumar Nema and Indrajeet Singhvi

ABSTRACT

Organic solvents are most frequently employed in spectrophotometric analyses. They may be sources of pollution. Some of them may be toxic while others may be costlier. Volatility may be a source of inaccuracy in spectrophotometric estimations. In the present investigation, it was proposed to solubilize Nimesulide by use of mixed solvency concept. Nimesulide shows maximum absorbance in the concentration range of 10-50μg/ml at 390 nm. Method of analyses have been validated for different parameters like linearity, accuracy, precision, LOD and LOQ. The percent drug estimated in tablet formulation of Batch-I and of Batch-II were 100.16±0.260and 99.96±0.283 respectively. The range of percent recoveries varied from 100.36±0.175 to 101.23±0.371.Sodium Benzoate and phenol do not interfere above300 nm. The analytical method was found to be simple, safe (free from toxicity), economic and eco-friendly.

Keywords: Nimesulide, UV-Spectrophotometry, solid dosage formulation, mixed solvency concept.