ANTIUROLITHIATIC ACTIVITY OF GREWIA FLAVESCENS JUSS. ON ETHYLENE GLYCOL INDUCED UROLITHIASIS IN RATS.

G. N. Pramodini*, Dr. Shaik Mohammed Khasim and Dr. Parwez Alam

ABSTRACT

Objective: To study the antiurolithiatic activity of grewia flavescens (tiliaceae) in ethylene glycol induced urolithiasis in male wistar rats. Method: The urolithiasis was induced in rats by oral feeding of ethylene glycolated water (0.75%) for 28 days. Ethanolic extract of EEGF (100mg/kg, 200mg/kg, and 400mg/kg) was administered orally from 1st day to 28th. Results: it was observed that the inducing agent ethylene glycol elevated the formation of kidney stones and kidney inflammation which resulted in decrease in urine output. Treatment with ethanolic extract of EEGF from 15th days significantly (P<0.001) reduced the kidney stones and resulted in restoring of kidney activity such as glomeruli and renal tube functioning. Conclusion: 28 days administration of ethylene glycol showed calcium oxalate crystals in renal tubules in negative control group. Treatment with EEGF decreases the calcium oxalate crystals on dose dependent manner and restored activity of glomeruli and renal tube functioning. Thus the results of our study reveal that EEGF effective in treatment of ethylene glycol induced urolithiasis in rats when compared to the standard drug cystone.

Keywords: Antiurolithiasis, Grewia flavescens, Tiliaceae, Ethylene glycol.