ANTI-ULCER EFFECT OF FOUR INDIAN MEDICINAL HERBAL PLANT EXTRACTS IN ETHANOL INDUCED ULCER AND LEVELS OF ANTIOXIDANT ENZYMES IN WISTER RATS

Saurabh Dubey and Shweta Sao*

ABSTRACT

This study was aimed to evaluate the efficacy of methanolic extracts of four Indian medicinal plant extracts Nyctanthes arbor-tristis, Moringa Olefera, Catharanthus roseus and Jetropha curcas for their Antiulcer and Anti-oxidant activities. Seven groups of male wister rats were used for the study, each group contains six rats. The ulcer was induced in test groups of rats by the administration of 1ml of absolute ethanol after 24 hours of fasting. The animals were sacrificed and ulcer intensity and ulcer index were measured and compared after treatment with methanolic extract of these four medicinal plants. The Anti-oxidant levels (Superoxide dismutase and Catalase) were also evaluated and compared. The comparative evaluation shows that Catharanthus roseus and Moringa olefera causes marked reduction in ulcer severity, and also increases the levels of Antioxidant enzymes.

Keywords: Nyctanthes arbor-tristis, Moringa olefera, Catharanthus roseus Jetropha curcas, Anti- oxidant enzymes.