EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

DESIGN, SYNTHESIS AND CHEMICAL HYDROLYSIS STUDY OF CODRUGS OF PROPRANOLOL WITH METFORMIN.

Ganesh S. Andhale*, Giles D., Amit K. Das, Anirbandeep Bose and Basavraj Metikurki

ABSTRACT

In the present study we have synthesized ester prodrugs (Pa-h) of Propranolol (I) by using pthalic anhydride and derivatives of succinic and maleic anhydride. Different codrugs (COa-h) were synthesized from prodrugs of propranolol. All the codrugs were characterized by melting point, FTIR, NMR and Mass Spectroscopy. The chemical hydrolysis of COa-h were investigated at the pH 1.2, 6.8 and 7.4. Presence of maleate, methyl maleate, dimethyl maleate and succinate group as linker possess high hydrolysis when compared to that of other substitutes. Among the synthesized codrugs, COd is found to be the best one among the series.

Keywords: Chemical hydrolysis, codrugs, metformin, prodrugs, propranolol.


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