QUANTITATIVE ANALYSIS OF VALERENIC ACID IN HERBAL PRODUCTS ON BOSNIAN MARKET USING HPLC METHOD

Maja Paši?- Kulenovi?*, Bekir Behlulovi? and Larisa Alagi?-Džambi?

ABSTRACT

Valerian (Valeriana officinalis L.) has been used in traditional medicine as a mild sedative and sleep-promoting agent. Sesquiterpenic acids expressed as valerenic acid consist of three fractions valerenic acid, cetoxyvalerenic acid and hydroxyvalerenic acid. These characteristic components of valerian are used as analytical markers to evaluate the quality of valerian preparations. Ten different valerian herbal products, in form of tincture, drops, capsules and film coated tablets available on the market have been tested on content of valerenic acids as analytical marker using high performance liquid chromatography (HPLC) method described in Valerian monographs of European Pharmacopoeia and United States Pharmacopoeia (USP).

Keywords: Valeriana officinalis, valerenic acid, HPLC method.