INTRANASAL DEXMEDITOMIDINE AND INTRANASAL MIDAZOLAM AS PREMEDICATION IN PEDIATRIC SURGICAL PATIENTS

Dr. Kharat Mohammed Bhat, Dr. Samiksha Khanooja* and Dr. Irshad Yousuf

ABSTRACT

Background: Many routes and drugs have been studied for premedication in pediatric surgical patients. Intranasal being one of them. Ease of administration makes it one of the preffered routes. Objectives: To evaluate the safety and efficacy of midazolam, and dexmedetomidine as intranasal premedication in paediatric surgical patients -to study their hemodynamics and respiratory consequences and post anaesthesia recovery in paediatric patients. Method: It was a prospective, randomized double blind study. 50 children aged 1 to 8 years were studied in each group(midazolam and dexmedetomidine). Results: The intranasal midazolam 0.2 mg/kg and dexmedetomidine 1.5 μg/kg produced effective and significant sedation which was seen at 30 min in dexmedetomidine group and at 15 min in midazolam groups and this change was maintained in all groups at 45 min and at the time of induction of anesthesia In conclusion Conclusion: we found that midazolam, and dexmedetomidine produced adequate sedation with little side effects. We prefer to use midazolam due its efficacy and safety as well as availability and its low price in comparison to dexmedetomidine. Overall recovery profile was better in the patients who received dexmedetomidine.

Keywords: Intranasal, dexmedetomidine, midazolam, premedication, pediatric.