A REVIEW TO ASSESS THE CURRENT CONUNDRUMS OF THROMBOPROPHYLAXIS ASSOCIATED WITH WARFARIN THERAPY IN ATRIAL FIBRILLATION PATIENTS

Sabari Nath K. F.* and Gerllin Mary George

ABSTRACT

Warfarin is a potent vitamin k antagonist that has been widely used for anticoagulation. One of the major indication of warfarin is its prophylaxis use in stroke for atrial fibrillation patients. With the advent of novel oral anticoagulants, thromboprophylaxis treatment for atrial fibrillation has become more intriguing and sophisticated. Due to the narrow therapeutic index of warfarin and a lack of studies associated with newer oral anticoagulants, warfarin still presents a number of predicaments for anticoagulation in Indian atrial fibrillation patients. Our study mainly focuses on these complexities of warfarin therapy from an Indian perspective.

Keywords: Warfarin, Atrial fibrillation, International normalized ratio.