SYNTHESIS, CHARACTERIZATION AND ANTIMITOTIC ACTIVITY OF CYANOACETYL HYDRAZONE DERIVATIVES

K. Sundaresan, S. Umamatheswari and K. Tharini*

ABSTRACT

The present investigations describe about the synthesis, characterization and biological studies of novel cyanoacetyl hydrazone derivatives. However their derivatives have been used in the fields of medicinal and pharmaceutical chemistry and reported to exhibit a variety of biological activities. The structures of all the synthesized compounds were elucidated by using spectral data. The synthesized compound was subjected to preliminary antimitotic studies by Allium cepa root MERISTAMATIC CELLS. The result from the study showed that the cyanoacetyl hydrazones had excellent anti-mitotic activity that was comparable to the activity of methotrexate. Mito inhibitory effect of the compounds were observed in higher concentrations. Our findings support the reported therapeutic use of these compounds as a antimitotic or anticancer agent in the Indian system of medicine.

Keywords: cyanoacetyl hydrazone, antimitotic activity, meristamatic cells, methotrexate, mitotic Index.