THE AMELIORATIVE ROLE OF MORINGA OLEIFERA ON THE ABNORMALITIES INDUCED BY ASPARTAME IN RATS: II. LIVER AND KIDNEY STATUS IN RAT

Gehan S. Moram*, Heba Barakat, Nahla H. Ali

ABSTRACT

This study aimed to investigate the ameliorative effect of Moringa oleifera (MO) aqueous leaves extract against the damage induced by the sweetener aspartame (AM) on liver and kidney functions and oxidative stresses in adult male albino rats. AM and MO was administered (75 and 500 mg/ Kg body weight) as a daily oral dose, respectively. Rats were divided into five groups; namely, saline control (Sc), AM, Protection (Pr), Improvement (Im) and treatment (Tr). Results of the study suggested that MO treatments had a hepato renal protection as indicated by the enzymatic and non-enzymatic function tests and oxidant antioxidant status compared to AM administered group (P<0.05). Interestingly, the group of the Tr design exerted almost the most protection of liver and kidney compared to the other treated groups (Pr and Im). The aqueous leaves extract of MO administration indicated both preventative as well as curative hepato- and renal protective activities.

Keywords: aspartame, Moringa oleifera, liver, kidney, oxidative stress.