IN VIVO EVALUATION OF COMBINED DOSAGE OF APIUM GRAVEOLENS DULCE AND BRYOPHYLLUM PINNATUM KURZ FOR ANTIGOUT ACTIVITY

Rhema Niteen Dongre*, Dr. S. B. Patil, Dr. N. S. Naikwade

ABSTRACT

The present study aimed at the In vivo evaluation of combined dosage of Apium graveolens dulce and Bryophyllum pinnatum kurz for antigout activity. The activity was performed for 3 days using ethanolic extract of leaves and stalk of Apium graveolens dulce and fresh juice extract of leaves of Bryophyllum pinnatum kurz at 500mg/kg and 106.4mg/kg doses. The study conducted against Albino rats (Wistar strain). In this study Allopurinol was used as a standard drug. The results were noted in terms of highest reduction in uric acid formation showing reduction in BUN, creatinine, uric acid and Xanthine oxidase level in serum and uric acid in urine. The combination of ethanolic extract of leaves and stalk of Apium graveolens dulce and fresh juice extract of leaves of Bryophyllum pinnatum kurz shows significant effect by reducing the formation of uric acid.

Keywords: Allopurinol, Apium graveolens dulce, Bryophyllum pinnatum kurz, Potassium oxonate.