ANTI-HYPERTENSIVE EFFECTS OF LYCOPENE ON FRUCTOSE INDUCED HYPERTENSIVE RATS.

Mayank Bhatt, Sayanti Sau, Shivalinge Gowda KP*

ABSTRACT

Based on the ethno pharmacological use of lycopene in the treatment of hypertension, this study was designed to evaluate its antihypertensive effects in rats. Rats were divided into 5 groups (n=6). Group I was considered as normal control, II received lycopene (30 mg/kg p.o.), III received fructose (10 % w/v p.o.), IV lycopene + fructose (30 mg/kg p.o.+10 % w/v p.o.) and captopril (20 mg/kg p.o.) for 6 week. After 24 h animals were separated and invasive BP (Carotid artery cannulation) and ECG was measured by AD instruments data acquisition system. After cannulation the animals were connected to the data acquisition system and recorded the BP and ECG. After the experiment the rats were sacrificed using ketamine (100 mg/kg) overdose. From the results of this study, it was concluded that Lycopene has shown significant decrease in systolic, diastolic and mean arterial blood pressure when given to the hypertensive rat. Lycopene has given significant changes in QRS and RR interval segments of the ECG of hypertensive rat.

Keywords: Lycopene, Hypertension, ECG, Carotid Artery Cannulation.