COMPARATIVE STUDY FOR MANAGEMENT OF ORAL SUBMUCOSAL FIBROSIS BY USING TWO DIFFERENT DRUG REGIMENS

*Dr. Kundan Shah, Dr. Anand Mangalgi, Dr. Sudha Halkai, Dr. Deepika mallasure, Dr. Viquar Ahmed and Dr. Neelam singh

ABSTRACT

Background: Oral submucous fibrosis (OSMF) is a chronic debilitating and potentially malignant condition of the oral cavity. It is resistant and progressive affecting the entire oral cavity that sometimes causes a gradual reduction in mouth opening that may even extend up to the pharynx. Although the medical treatment is not completely systematized, optimal doses of its treatment with local injection of corticosteroids with hyaluronidase or placental extract is effective to some extent. However, a combination of oral drugs along with locally injectable drugs shows better long-term results than either agents used individually. Materials and Methods: A total of 60 patients diagnosed with OSMF were divided into 2 groups, group 1 patients receiving oral drugs along and group 2 were treated by administering an intralesional injection of dexamethasone2 ml, hyaluronidase 1500 IU with 0.5 ml lignocaine HCL injected intralesionally weekly for 6 months along with the oral drugs used for group 1 patients. Results: Improvement in the patient’s mouth opening with Definite reduction in burning sensation, painful ulceration and blanching of oral mucosa and patient followed up for an average of 6 months. Conclusion: Injection of hyaluronidase with dexamethasone is an effective method of managing OSMF and can possibly eliminate the morbidity associated with surgical management.

Keywords: Dexamethasone, hyaluronidase, oral submucousal fibrosis, oral drugs.