FORMULATION DEVELOPMENT USING QBD APPROACH AND EVALUATION FOR PREPARATION OF ROFECOXIB ETHOSOMES FOR TOPICAL GEL ADMINISTRATION

*Pingale Prashant. L., Boraste Sahebrao S., Walke Prashant S.

ABSTRACT

Transdermal delivery embodies an attractive alternative to oral delivery of drugs and is composed to provide an alternative to hypodermic injection too. Transdermal delivery has a variety of benefits compared with the oral route. In specific, it is used when there is a significant first-pass effect of the liver that can prematurely metabolize drugs. Transdermal delivery also has leads over hypodermic injections, which are painful, generate dangerous medical waste and stance the risk of disease transmission by needle re-use, especially in developing countries. In a cited research work, we attempted to prepare Rofecoxib Ethosomes for Topical Gel Administration using QbD approach and Evaluation of prepared ethosomes.

Keywords: QbD, Rofecoxib Ethosomes, ethosomes.