SYNTHESIS, CHARACTERIZATION & ANTIMICROBIAL SCREENING OF 2,5- DICHLORO-1- (N-SUBSTITUTED PHENYL)-1H- PYRROLE-3,4-DICARBALDEHYDES.

*A. P. Rajput, A. R. Kankhare and D. V. Nagarale

ABSTRACT

The synthesis of Nitrile derivatives by using Ceric Ammonium Nitrate (CAN) catalyst have some attractive features such as simple to operate, fast reaction rate, nontoxic, inexpensive and environmentally friendly catalyst. The pharmacological importance and lack of convenient, efficient procedures prompted us to develop a concise, straightforward and economical route for the synthesis of 2,5-dichloro-1-(N-substituted phenyl)-3,4-dicarbonitriles.

Keywords: CAN, Vilsmeier Haack Reaction, Nitrile derivatives, Pyrroles.