FORMULATION AND CHARACTERIZATION OF PLA NANOPARTICLES OF TEMOZOLOMIDE

Gajanan Mehare*, Sengodan Tamizharasi, T. Sivakumar, Snehal Sawarkar, Piyush Chudiwal

ABSTRACT

In this study, we formulated and investigated the Temozolomide (TM) loaded PLA Lactic acid (PLA) nanoparticles prepared by solvent evaporation technique. The prepared nanoparticles were characterized by using X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) and Differential scanning colorimetry which showed that such nanoparticles had a smooth surface and a spherical geometry. Result indicated that Temozolomide trapped in the nanoparticles existed in an amorphous or disordered-crystalline status in the polymer matrix. The release profiles of Temozolomide from nanoparticles resulted in biphasic patterns. After an initial burst, a continuous drug release was observed for up to 1 month.

Keywords: Temozolomide (TM); PLA, Emulsifying-solvent evaporation; Nanoparticles.