SUPERBUGS AGAINST CEPHALOSPORIN, OBSERVATIONAL STUDY AT TERTIARY CARE HOSPITAL IN INDIA.

Ashishkumar C Zala*, Prakash Malam, Ruchita Manvar, Dhruv Patel, Dharana Patel, N D Kantharia.

ABSTRACT

Background: The Cephalosporin antibiotics have become a major part of the antibiotic formulary for hospitals in developing countries. The numbers of bacteria developing resistance against Beta lactam antibiotics. Objective: To evaluate the sensitivity pattern of Cephalosporin antibiotics in tertiary care teaching Hospital. Method: This study was conducted for a period of 6 months in a tertiary care hospital in Surat. The clinically suspected laboratory samples were collected from the patients and subjected to culture and antibiotic sensitivity testing. Anti-microbial susceptibility testing was done on Mueller Hinton agar plate by Kirby Bauer Disc diffusion method and the samples include pus, urine, blood, semen, endotracheal tube, catheter tip and sputum. Results: The total 685 clinical samples were collected; out of them 23.4% are pus, 14.6% sputum, 7.3% blood, 21.9% urine, faeces 5.8%, 13.1% endotracheal tube, 6.6% catheter tip and 2.9% of semen samples. Among the 160 Pus samples – 100 resistances, 100 Sputum samples -60 resistance, 50 Blood samples – 30 resistance, 150 Urine samples – 80 resistance, 50 semen samples -30 resistance , 90 endotracheal tube samples -30 resistance and 45 catheter tip -30 samples have shown resistance. Conclusion: The study concludes that the ceftazidime and fourth generation Cephalosporins have better sensitivity when compared to first, second and some third generation Cephalosporins. Here by, the present study explores the emergence of sensitivity and resistance of organisms to Cephalosporins in a tertiary care hospital.

Keywords: Cephalosporin, Antimicrobial resistance (AMR).