PCOS, TYPE II DIBETES MELLITUS, OBESITY COEXISTENCE: AN METABOLIC DISASTER & A WAY THROUGH IT

Sushama D. Patil*, Dr. A. S. Jain, Dr. Rahul Somani, Dr. S. D. Sawant

ABSTRACT

Polycystic ovary syndrome (PCOS) is one of the most frequently encountered endocrine disorder occurring in women of reproductive age. Primary clinical manifestations are menstrual irregularities, infertility, and hirsutism. However if not treated properly, a patient is at risk for type 2 diabetes, obesity, dyslipidemia and cardiovascular disease. The hallmarks of this metabolic disaster are hyperandrogenism and hyperinsulinemia. Great controversy exists as to which state precedes the other. Research consistently demonstrates that weight loss and dietary changes appear to affect all parameters of hormonal and metabolic fluctuation. In this review we have attempted to cover pathophysiology of this disaster in brief. Moreover we have discussed various old, new and future therapeutic ways to come out of these endocrine and metabolic complications.

Keywords: PCOS, Type II Diabetes mellitus, Obesity, Dyslipidemia, treatments.