A REVIEW ON ANALYTICAL METHODS BASED ON HYDROTROPIC PHENOMENON

K R Sreejith*, P L Rajagopal, K P Jyolsna, M K Sharbina

ABSTRACT

Solubility is one of the important parameter to achieve desired concentration of drug in systemic for pharmacological response to be shown. Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. There are many techniques which are used to enhance the aqueous solubility. The ability to increase aqueous solubility can thus be a valuable aid to increasing efficiency and/or reducing side effects for certain drugs. This is true for parentally, topically and orally administered solutions. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. Hydrotropy is one of the solubility enhancement techniques which enhance solubility to many folds with use of hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. and have many advantages like, it does not require chemical modification of hydrophobic drugs, use of organic solvents or preparation of emulsion system etc.

Keywords: Hydrotropy, Solubility, Hydrophobic drugs, Hydrotropes, Solubility enhancement.