MICROWAVE- ASSISTED SYNTHESIS OF NOVEL CHALCONE DERIVATIVES AND STUDYING OF SOME OF THEIR ANTIMICROBIAL ACTIVITIES

F. M. A. Soliman, A. F. Mohamed, M. A. Mohamed, N. T. Dawood and *L. I. Sadik

ABSTRACT

A novel approach for the synthesis of a series of chalcones (3a-f) by the reaction of acetophenones (1a-c) with different aromatic aldehydes (2a-c) as well as barbituric acid (1d) with terphthalaldehyde (2d) under thermal solvent-free conditions. All the synthesized compounds were characterized using elemental analysis and spectral data (IR,1H-NMR, 13C-NMR, and mass spectrometry). The synthesized compounds were tested for their antimicrobial activity by the disk diffusion assay against Gram-positive, Gram-negative strains of bacteria as well as fungi. The investigation of antimicrobial and antifungal screening revealed that most compounds showed potent antimicrobial and five antifungal activities respectively. Among the screened compounds (3a-c and 3f) showed more potent activity (IZ) nearly to that of standard antibiotics Chloramphenicol, Gentamycin, Sxt and Ketonazol.

Keywords: Thermal solvent-free conditions, Green chemistry, Chalcones, Antimicrobial activity.