NEUROPROTECTIVE AND ANTITOXIC POTENTIAL OF HYDROMETHANOLIC EXTRACT OF ALLIUM CEPA IN EXPERIMENTAL RATS

Ilochi Ogadinma*, Arthur Nwafor Chuemere, Ekwem Ikechukwu, Bassey Samuel

ABSTRACT

This research studied the neuroprotective potential of Allium cepa hydromethanolic extract on neurotoxicity due to lead acetate treatment. 30 male wistar rats were used. The animals were grouped simple randomly into 6 separate compartments. The experimental period lasted for 42 days during which the animals were subjected to various treatments. From A the control administered normal saline, B administered Allium cepa extract 100mg/kg, C administered lead acetate 500mg/kg. D, E and F co-administered 100,150 and 200 mg/kg of Allium cepa extract and lead acetate 500mg/kg. The biomarkers assayed for include protein carbonyl (PC), malondialdehyde (MDA),isoprostanes (F2IsoP) and reduced glutathione (GSH). With data significantly different at a confidence interval of 95%, there was a significant increase in GSH, but a decrease in PC, MDA and F2IsoP in the groups treated with Allium cepa extract 100mgkg and Allium cepa 150 and 200mg/kg co-administered lead 500mg/kg.lead acetate treatment alone significantly increased PC, MDA and F2IsoP but decreased GSH compared to control. Allium cepa, at the studied dose, can effectively be applied in neurotoxicity.

Keywords: Allium cepa hydromethanolic, protein carbonyl (PC).