ADENOCARCINOMA OF THE PROSTATE IN NIGERIAN IGBOS; A CLINICO-PATHOLOGIC REVIEW

*Nnadi I. G., Egejuru R. O. and Anyaeze C. M.

ABSTRACT

Aim: To describe the demographic, clinical and histopathological characteristics of carcinoma of the prostate among men of Eastern Nigeria. Methodology: The surgical day book, request form and histology reports were perused and the demographic, clinical, chemical pathology reports of the total PSA (PSA) values were recorded. DRE was carried out by Urologists and abnormal DRE findings suspicious of prostate cancer were documented. Results: This is a histopathological analysis of 265 consecutive cases of carcinoma of Prostate (Cap) in men of Nigeria Igbos between April 2010 and March 2016 at Federal Medical Centre Owerri. The mean age was 70.7±11.0 with age range of 4 to 104 years. The peak age group was 71-80 years followed by 61-70 years. The mean total prostate-specific antigen (PSA) was 47.7±30.9ngml-1 with a range of 2.0 to 512ngml-1. The mean duration of symptoms was 27.6 months with a range of 2 to 180 months. Lower urinary tracts symptoms were reported by 225 (84.9%) patients. The abnormal digital rectal examination was present in 47 (17.73%) cases. Metastatic disease was found in 15 cases (5.7%). The histological variants of the CaP were adenocarcinoma 98.87% (262 cases), and one case (0.38%) each for Adenoid cystic carcinoma and Mucinous carcinoma. A suspected case of Primary Melanoma of the prostate was also present.

Keywords: Prostate adenocarcinoma, southeast, Owerri, Histopathology.