SOLID LIPID NANOPARTICLE: A POTENTIAL APPROACH IN DRUG DELIVERY SYSTEM

Prashant Pandey*, Prakash Chandra Gupta, Sanjay Yadav

ABSTRACT

To improve the solubility and bioavailability solid lipid nanoparticles (SLNs) are the new approach in drug delivery system. Since a decade, a lot of research works are performed to utilize solid lipid nanoparticles as alternative drug delivery system to colloidal drug delivery systems such as lipid emulsions, liposomes and polymeric nanoparticles. SLNs offer great promise to controlled drug delivery and site specific and gene delivery. Nanostructured lipid carrier, lipid drug conjugates, polymer lipid hybrid nanoparticles are the new emerging drug delivery system. This review concentrated on drug incorporation models, advancement in lipid nanoparticles, method of preparation, secondary production steps, characterization, application and future of SLNs. This review presents a broad treatment of solid lipid nanoparticles discussing their advantages, limitations.

Keywords: Solid lipid nanoparticles (SLNs), Polymer lipid hybrid nanoparticles (PLNs), Acoustic method, Membrane Contractor technique.