SERUM GAMMA GLUTAMYL TRANSFERASE ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES ASSOCIATED WITH DIABETIC MELLITUS

Ravoori Saideswar Rao* and Vanita Lal**

ABSTRACT

Back ground: Gamma glutamyl tranaferase(GGT) is a widely used marker for liver function and is correlated with alcohol intake. An increase GGT activity is linked with influx of GGT–carrying Lipoproteins into plaque. Materials and Methods: The study design is a cross sectional study with 280 participants consisting of a 3 groups. Group-1 Cardiovascular disease (CVD) without diabetes,Group-2 CVD with diabetes,Group-3 Healthy individuals. The analysis of GGT, RBS, lipid profile ,SGOT and SGPT were done in central hospital laboratory of SRMC&RI by using standard kits in Dimension RxL autoanalyser. The results were expressed as mean ±SD.The data analysis was done by using ANOVA and Pearson’s correlation. Result: We observed a statistically significant increase (p ˂ 0.001) in serum GGT levels in group 1& 2 compared to group 3. There is no statistically significant in serum GGT levels in cardiovascular disease with diabetes and without diabetes. There is good significant correlation between the GGT with total cholesterol(r = 1). A week correlation was obtained between GGT and triglycerides, LDL and negatively correlated with HDL. Conclusion: Higher Gamma glutamyl transferase levels are associated to cardiovascular disease in people with and without diabetes.There is increased concentration of GGT in serum compared to healthy individuals.

Keywords: Gamma Glutamyl Transferase, Oxidative Stress, Atherosclerosis, Cardiovascular Disease.