SYNTHESIS OF NOVEL 10-[3’- (N-SUBSTITUTED BUTYL)-3-CHLORO-4-FLUORO]-ACRIDONES TO TARGET HEPATOCELLULAR CARCINOMA

Anita Kurup, *Iswar Hazarika, V. Murugan, Kalpana Divakar and Geetha K. M.

ABSTRACT

Hepatocellular carcinoma (HCC) has become a global health problem requiring a potent chemotherapeutic agent. Acridone and its derivatives are important anthracene analogue heterocyclic compounds as with high DNA affinity and interactive properties making it an important pharamocophore for designing several chemotherapeutic agents. Several 9-acridone derivatives with or without an alkyl side chain attached to the N-position have been found to exhibit antioxidant activities. So, several novel N10 substituted -4- Methyl acridones were synthesized and evaluated for its anticancer activity in HepG2 cell lines and its correlation with antioxidant scavenging property. Results suggested that, all the synthesized compounds have a potent cytotoxic activity with a significantly less IC50 as compared to the standard sorafenib.

Keywords: Hepatocellular carcinoma; Acridone; HepG2 cell line; Anticancer; antioxidant; Sorafenib.