EXHAUSTION OF PERIPHERAL BLOOD IMMUNE CELLS IN CHBV AND CHCV PATIENTS: AN EVALUATION OF IFN-?LPHA AND IFN-GAMMA PRODUCTION.

Adilov D.G., Rozumbetov R.J.*, Aripova T.U., Ismailova A.A., Petrova T.A., Kasimova M.S., Rakhimjanov A.A.

ABSTRACT

It’s common knowledge that, interferons (IFN) are crucial cytokines, which control various physiological processes in many cells. On top of that, they are pivotal players in pathogenesis of many diseases, namely viral and oncological. We have studied spontaneous and induced production of interferons in chronic hepatitis patients. In chronic viral hepatitis C and B patients (CHCV and CHBV), the induced level of IFN-α and IFN-γ production was significantly lower than in the control group, which gives grounds for suggesting that peripheral blood leukocytes are exhausted in patients with chronic viral hepatitis.

Keywords: Interferon, spontaneous production, induced production, viral hepatitis, immune cell exhaustion.