HEPATITIS B AND HUMAN IMMUNODEFICIENCY VIRUS (HIV) CO-INFECTION IN PORT HARCOURT METROPOLIS, NIGERIA: A COMPARISON OF THEIR RENAL INDICES ASSESSMENT

Ayodele Martins B. O., Adegoke Adebayo O., Olugbenga Bamigbowu, Aaron Umasoye U.* and Abah Austin

ABSTRACT

HIV and HBV co-infection has emerged over last two decades as a serious public health challenge. This study was done to determine the renal function indicators in subjects who are human immunodeficiency (HIV) and Hepatitis B surface antigen (HBsAg) positive. One hundred (100) subjects made up of Twenty five (25) each for HIV positive, Hepatitis B surface antigen positive and HIV-Hepatitis Virus (HBV) co-infected and HIV and HBsAg negative individuals (Controls) had their sodium, Potassium, Chloride, bicarbonate, Urea and creatinine determined using VITROS auto analyser 250/350/950/5, 1 FS and 4600 Chemistry Systems and the VITROS 5600 Integrated System manufactured by Ortho-Clinical Diagnostics, Inc. The results showed that there was significant difference (P<0.05) in sodium, Potassium, Chloride, bicarbonate concentrations of HIV positive, HBV positive and HIV-HBV co-infected patients when compared to their respective controls while there was no difference in their Urea and Creatinine concentrations. The study has shown that HIV and HBsAg positive and HIV-HBV co-infection cause electrolyte imbalance. Therefore, there is need for adequate awareness among health care providers and the public on the effect of the spread of these viral infections, the consequence of their co-infection and their modes of prevention.

Keywords: HIV, Hepatitis B, Infection, Renal Function, Port Harcourt.