EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

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Abstract

SYNTHESIS, ANALGESIC, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF NOVEL PYRAZOLINE DERIVATIVES.

Zakaria K. Abdel –Samii*, Hanan A. Abdel- Fattah*, Reham M. Abdel- Rehem and Hisham A. Khalifa

ABSTRACT

A series of novel pyrazoline derivatives 3a-p were synthesized via the reaction of aryl hydrazine derivatives 2a-d with chalcones 1a-d. The new compounds were screened for their analgesic, anti- inflammatory and antimicrobial activities. Compounds 3a and 3l showed a greater analgesic activity than Celecoxib. Moreover compounds 3a and 3n showed good anti-inflammatory compared to Celecoxib.However their efficacies were associated with lower gastric ulcerogenecity compared with Indomethacin.Compounds 3e and 3f showed high activities against both gram positive bacteria (Staphylococcus aureus) and gram
negative bacteria (Pseudomonas aruginosa) while compounds3e, 3k and 3 m have high activity against Candida albicans.

Keywords: Analgesic, anti-inflammatory, antimicrobial activity, synthesis, pyrazoline derivatives.


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SJIF Impact Factor: 7.065

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