EVALUATION OF SUSTAINED RELEASE BILAYER TABLETS OF METFORMIN HYDROCHLORIDE AND GLIMEPRIDE

K. Mohan Kumar*, S. Thilagavathy and M. Ranga Priya

ABSTRACT

The present research work was aimed to establish bi layer tablets containing Metformin HCl as sustained release and Glimepiride as immediate release layer for diabetes therapy. Sustained layer of the tablet were prepared by wet granulation method using different polymers of HPMC K 100M and ethylcellulose as bio adhesive polymers and immediate release layer were prepared by direct compression using super disintergrants such as sodium starch glycolate. Tablets were evaluated for both pre compression and post compression parameters. In-vitro drug release from the formulations was studied by dissolution method. The result showed that optimization of polymers namely HPMC and Ethyl cellulose in sustained layer can control the release of drug. The physico – chemical property of the finished product complies with the standard limit. The obtained were fitted into higuchi’s models, zero order, first order and korrsmeyer-peppas. The present study concluded that bi-layer of Glimepride and Metformin HCL can have a good to extent metabolism and as an alternative to the conventional dosage form.

Keywords: Metformin HCl, Glimepiride, bi layer tablets, super disintergrants.