LEVEL OF BIOCHEMICAL BONE MARKERS IN POSTMENOPAUSAL WOMEN IN EASTERN U.P. (INDIA): AN INDICATOR OF OSTEOPOROSIS

Sadhna Ajay*, Monika Gupta and Reena Sharma

ABSTRACT

Present study was carried out to know the prevalence of osteoporosis in postmenopausal women in eastern part of U.P. state of India. A total of 120 postmenopausal women were included in this study. 60 nonpregnant, healthy, premenopausal women served as controls. Biochemical Bone markers such as serum calcium, serum phosphorus and serum Alkaline phosphatase were estimated in all the cases and controls to know the status of osteoporosis. Serum calcium was decreased in postmenopausal women (mean± SD 8.47±0.83 mg/dl) when compared to controls (mean±SD 9.68± 1.94 mg/dl), with ‘p’ value <0.05. Serum phosphorus was insignificantly (p>0.05) raised in postmenopausal women with mean ±SD level 3.82±2.62mg/dl as compared to controls (mean±SD; 3.78 ±1.57mg/dl). Serum Alkaline phosphatase levels were increased in cases with 87.36 ±18.02 IU/L compared to that of controls, 68.27± 8.12IU/L (mean±SD). This difference was statistically significant with a ‘p’ value of < 0.001.Thus biochemical bone markers do indicate the presence of osteoporosis in postmenopausal females of this region.

Keywords: Osteoporosis, Postmenopause, Body Mass Index(BMI), Alkaline Phosphatase (ALP).