INTRANASAL MIDAZOLAM, FENTANYL AND DEXMEDETOMIDINE AS A PREMEDICATION IN PAEDIATRIC SURGICAL PATIENTS

Usma Jabeen, Talib Khan, Khairat Mohammad*, Parvaiz A Thoker, Samiksra

ABSTRACT

Background: For providing premedication to pediatric surgical patients, various drugs and many routes have been studied. Intranasal route is one of them. It’s one of the preferred routes because of the ease of administration. Objectives: To evaluate the safety and efficacy of midazolam, fentanyl and dexmedetomidine as intranasal premedication in pediatric surgical patients, to study their hemodynamics and respiratory consequences in paediatric patients and their effects on post anaesthesia recovery. Methods: Prospective, randomized double blind study.50 children of 2-8 years were studied in each group. Results and Conclusion: We found that midazolam, fentanyl and dexmedetomidine produced adequate sedation with little side effects. We prefer to use midazolam due its efficacy and safety as well as availability and its low price in comparison to fentanyl and dexmedetomidine. Overall recovery profile was better in patients who received dexmedetomidine.

Keywords: Midazolam, fentanyl and dexmedetomidine.