EFFECTS OF STRONTIUM CHLORIDE HEXAHYDRATE IN CAENORHABDITIS ELEGANS INDIVIDUALS AS A MODEL FOR SKIN AGING

*Rukiye Güner, Sibel Berksoy Hayta, Necati Özp?nar, Melih Akyol, Mustafa Tosun and 6Sedat Özçelik

ABSTRACT

Backround: Collagen destruction is related to the presence of matrix metalloproteinase (MMP) that are released by epidermal keratinocytes and dermal fibroblasts and the MMP-1 expression stimulated by ultraviolet radiation is provided by the protein kinase C-dependent (PKC)-dependent activation of transient receptor potential vanilloid 1 (TRPV-1) in human keratinocytes and subsequent calcium (Ca2+) transition. Strontium is a an alkaline-earth metal with chemical and biological behaviors similar to calcium. Objective: To investigate whether strontium chloride hexahydrate has anti-aging effects on Caenorhabditis elegans. Materials and Methods: After treatment with strontium solutions, the lifespan, physical development and pharynx pumping numbers of C.elegans were determined and compared with the control group. Results: An increase in strontium-exposed C.elegans depending on the dosage increase in their lifespans was specified. İt was determined that physical development in strontium-exposed C. elegans decreased depending on the dosage. It was specified that pharynx pumping count per minute decreased depending on the strontium dosage. Conclusion: Strontium chloride hexahydrate slowed down the developmental process of C.elegans and extended their lifespans. Strontium chloride hexahydrate may have a positive effect on skin aging in humans with similar mechanisms.

Keywords: Strontium, anti-aging, calcium, Caenorhabditis elegans, lifespan, skin aging.