SCREENING OF PHARMACOLOGICAL EFFECT OF METHANOL EXTRACT OF LEAVES OF LIBYAN CAPPARIS SPINOSA SUBSP ORIENTALIS (DUH.) JAFRI ON VITAL ISOLATED ORGANS

Salwa I. Eltawaty*, Mohamed-Elfatih A. Omare, Aisha Z. Almagboul, Amna E. H. Mohammad, Imad Eldin Mohamed Taj Eldin and Amjad M. A. A. Hamza

ABSTRACT

The present study was undertaken to evaluate the effect of the methanol extract of leaves of Capparis spinosa on vital isolated organs (Rabbit aorta strip, Rabbit jejunum, Rat uterus and Frog rectus abdominus muscle) with use of standard methods. Results: The results revealed that methanol extract of leaves of Capparis spinosa has weak cholinergic effect on isolated rabbit jejunum which completely antagonized with 10ng/ml Atropine. Also the result showed that the extract has a potentiating effect to the reference Nor-epinephrine at low doses up 400μg/ml which completely reversed to Nor-epinephrine antagonizing effect at high doses of ≥ 1600μg/ml. Conclusion: Methanol extract of leaves of Capparis spinosa has weak cholinergic effect on isolated rabbit smooth muscle, Norepinephrine potentiating effect at low doses and antagonizing effect on Nor-epinephrine at higher doses on isolated rabbit Aorta. The plant has no effect on tested isolated uterus and frog abdominus muscle.

Keywords: Capparis spinosa, Pharmacological effects, Isolated vital organs.